Barrier Effectiveness Test (In vitro)

Test Objective:
To ascertain the effectiveness of SYDERMA® to serve as a skin protectant against potentially harmfully environmental substances.

Test Method:
Filter membranes (0.45 micron pore size) were taped over aluminum foil electrodes. A 1 mm gap was left between the electrodes. The membranes were coated with 2 grams of SYDERMA® and dried until an electrical conductance of greater than 30,000 ohms was achieved. 0.1 ml of SYDERMA® was placed on top of the membrane and the time required to reach an electrical conductance of less than 10,000 ohms recorded. Control membranes were prepared for each test solution, omitting SYDERMA® and similarly tested. The analysis was terminated after 1 hour.

Interpretation of Assay:
The time for each Test Solution to penetrate SYDERMA® and the Control was observed and recorded. Penetration of SYDERMA® and the Control was confirmed by the reduction of an electrical conductance to less than 10,000 ohms.

Test Results:
SyDERMA®, served as an effective barrier to the penetration of 6 Test Solutions through treated membranes.


Observations:

Time to Penetration

Test Solution SyDERMA® Control Water >1 Hour Immediate Blood >1 Hour Immediate Urine >1 Hour Immediate Saliva >1 Hour Immediate 30% Alcohol >1 Hour Immediate 2% Detergent >1 Hour Immediate 30% Hydrogen Peroxide >1 Hour Immediate 20% Hydrochloride Acid >1 Hour Immediate